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WASHINGTON ( AP ) — Researchers have bring out a new clue to the case of Alzheimer ’s disease . The brains of people with the computer storage - surcharge form of dementedness are littered with a plaque made up of beta - amyloid , a sticky protein . But there long has been a question whether this is a suit of the disease or a side issue . Also involved are tangles of a protein name tau ; some scientists distrust this is the lawsuit .
Now , researcher have caused Alzheimer ’s symptoms in rats by injecting them with one particular bod of beta - amyloid . Injections with other form of beta - amyloid did not cause sickness , which may excuse why some people have beta - amyloid brass in their brains but do not show disease symptoms .
The findings by a squad led by Dr. Ganesh M. Shankar and Dr. Dennis J. Selkoe of Harvard Medical School were reported in Sunday ’s online variant of the journal Nature Medicine .
The researcher used extracts from the brain of citizenry who donated their body to medicament .
Forms of soluble beta - amyloid containing different numbers of atom , as well as indissoluble core of the brain plaque , were throw in into the nous of mice . There was no detectable effect from the insoluble plaque or the soluble one - molecule or three - molecule forms , the researchers detect .
But the two - molecule form of soluble beta - amyloid produced characteristic of Alzheimer ’s in the rat , they report .
Those rats had impaired retentiveness subprogram , specially for newly learned behaviour . When the mouse brains were inspected , the density learning ability cells was reduce by 47 percent with the genus Beta - amyloid seeming to affect synapses , the connections between cubicle that are all important for communication between them .
The inquiry , for the first time , showed the effect of a exceptional character of genus Beta - amyloid in the brain , said Dr. Marcelle Morrison - Bogorad , director of the division of neuroscience at the National Institute on Aging , which helped fund the research .
It was surprising that only one of the three types had an effect , she said in a telephone set interview .
Morrison - Bogorad enjoin the findings may avail explicate the find of plaque in the brains of people who do not develop dementia . For some time , doctors have wondered why they find some head in autopsy that are to a great extent coated with genus Beta - amyloid , but the individual did not have Alzheimer ’s .
The solution may lie in the two types of genus Beta - amyloid that did not cause symptom .
Now , the question is why one has the negative effect and not others .
" A lot of work needs to be done , '' Morrison - Bogorad said . " Nature keeps send us down paths that look straight at the beginning , but there are a lot of bender before we get to the end . ''
Dr. Richard J. Hodes , managing director of the National Institute on Aging , said that " while more research is needed to replicate and pass these findings , this study has put yet one more piece into home in the puzzle that is Alzheimer ’s . ''
In addition to the Institute on Aging , the research was fund by Science Foundation Ireland , Wellcome Trust , the McKnight and Ellison foundations and the Lefler Small Grant Fund .
